Abstract
This paper reviews recent progresses of the organic reactions catalyzed by transition metals in supercritical carbon dioxide (scCO2) in our group. The reactions include oxidation, reduction, carbonylation, radical addition, C-C coupling and cycloaddition reactions. All the reactions can be performed in scCO2 with equal or even better results than in conventional organic solvents, owing to the high diffusion and low viscosity of scCO2. The addition of suitable amount of co-solvents in scCO2 is necessary in most reactions, because it not only improves the solubility of transition metal salts in scCO2, but also regulates the ratio of products and raises the selectivity as well. Our work demonstrates that scCO2 and its modifier can be used as an alternative solvent for toxic organic solvents, and thus offers an environmentally friendly medium for the development of new synthetic methods in green organic chemistry.
Keywords: supercritical carbon dioxide, catalysis, wacker reaction, palladium-catalyzed oxidation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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