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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents

Author(s): Kalpana Singh, P.P. Sharma, A. Kumar, Anurag Chaudhary and R.K. Roy

Volume 13, Issue 8, 2013

Page: [1177 - 1194] Pages: 18

DOI: 10.2174/1389557511313080006

Price: $65

Abstract

4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase (TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized 4-aminoquinazoline analogs.

Keywords: 4-Aminoquinazoline, antitumor, apoptosis, cytotoxic, epidermal growth factor receptor, tyrosine kinase.


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