Abstract
4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase (TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized 4-aminoquinazoline analogs.
Keywords: 4-Aminoquinazoline, antitumor, apoptosis, cytotoxic, epidermal growth factor receptor, tyrosine kinase.
Mini-Reviews in Medicinal Chemistry
Title:4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents
Volume: 13 Issue: 8
Author(s): Kalpana Singh, P.P. Sharma, A. Kumar, Anurag Chaudhary and R.K. Roy
Affiliation:
Keywords: 4-Aminoquinazoline, antitumor, apoptosis, cytotoxic, epidermal growth factor receptor, tyrosine kinase.
Abstract: 4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase (TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized 4-aminoquinazoline analogs.
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Cite this article as:
Singh Kalpana, Sharma P.P., Kumar A., Chaudhary Anurag and Roy R.K., 4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2013; 13 (8) . https://dx.doi.org/10.2174/1389557511313080006
DOI https://dx.doi.org/10.2174/1389557511313080006 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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