P2O5/SiO2 : A Simple and Effective Catalyst for the Synthesis of N-substituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines

Leticia      J. Méndez; Alicia      S. Cánepa; Ruben      Rimada; Rodolfo      D. Bravo

doi:10.2174/1570178611310040003

Abstract

A synthesis of N-substituted 1-alkyl and 1-aryl 3-aminoisoquinolines by cyclocondensation of 2- acylphenylacetonitriles with aliphatic and aromatic amines using P2O5/SiO2 as catalysts is described. Selectivity, simplicity of operation and easy work-up are some advantages of this method.

Keywords: P2O5/SiO2, 3-aminoisoquinolines, 2-acylphenylacetonitriles.

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Letters in Organic Chemistry

Title:P₂O₅/SiO₂ : A Simple and Effective Catalyst for the Synthesis of N-substituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines

Volume: 10 Issue: 4

Author(s): Leticia J. Méndez, Alicia S. Cánepa, Ruben Rimada and Rodolfo D. Bravo

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Keywords: P2O5/SiO2, 3-aminoisoquinolines, 2-acylphenylacetonitriles.

Abstract: A synthesis of N-substituted 1-alkyl and 1-aryl 3-aminoisoquinolines by cyclocondensation of 2- acylphenylacetonitriles with aliphatic and aromatic amines using P2O5/SiO2 as catalysts is described. Selectivity, simplicity of operation and easy work-up are some advantages of this method.

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J. Méndez Leticia, S. Cánepa Alicia, Rimada Ruben and D. Bravo Rodolfo, P₂O₅/SiO₂ : A Simple and Effective Catalyst for the Synthesis of N-substituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines, Letters in Organic Chemistry 2013; 10 (4) . https://dx.doi.org/10.2174/1570178611310040003