Recent Progress in Rational Drug Design of Neuraminidase Inhibitors

Title: Recent Progress in Rational Drug Design of Neuraminidase Inhibitors

Volume: 14 Issue: 27

Author(s): Yu Liu, Jie Zhang and Wenfang Xu

Affiliation:

Keywords: Influenza virus, neuraminidase, neuraminidase inhibitor, pharmacophore model, antiviral agent

Abstract: Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.

Cite this article as:

Liu Yu, Zhang Jie and Xu Wenfang, Recent Progress in Rational Drug Design of Neuraminidase Inhibitors, Current Medicinal Chemistry 2007; 14 (27) . https://dx.doi.org/10.2174/092986707782360024