Abstract
The evolution of orthologous proteins opens a new era of research where the concepts of orthology and paralogy have become more and more substantial, as the whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is understood to be conserved among orthologs but it shows much more variability among paralogs. We used this laying claim to identify inter-species interactions based on orthologous protein networks which are crucial for understanding the evolution of orthologous proteins. We analyzed six classes of enzymatic protein sequence data using the node degrees of orthologous proteins. The results demonstrated the evolutionary importance of the fatty acid syntheses and the photosynthetic system in algae. Methods which have successfully exploited network structure at many different levels of detail are a cornerstone of systems biology.
Keywords: Orthology, Network degree, Enzyme, System biology.
Current Topics in Medicinal Chemistry
Title:Metabolism Evolution Based on Network Degrees of Orthologous Enzymes
Volume: 13 Issue: 5
Author(s): Kirtan Dave and Hetalkumar Panchal
Affiliation:
Keywords: Orthology, Network degree, Enzyme, System biology.
Abstract: The evolution of orthologous proteins opens a new era of research where the concepts of orthology and paralogy have become more and more substantial, as the whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is understood to be conserved among orthologs but it shows much more variability among paralogs. We used this laying claim to identify inter-species interactions based on orthologous protein networks which are crucial for understanding the evolution of orthologous proteins. We analyzed six classes of enzymatic protein sequence data using the node degrees of orthologous proteins. The results demonstrated the evolutionary importance of the fatty acid syntheses and the photosynthetic system in algae. Methods which have successfully exploited network structure at many different levels of detail are a cornerstone of systems biology.
Export Options
About this article
Cite this article as:
Dave Kirtan and Panchal Hetalkumar, Metabolism Evolution Based on Network Degrees of Orthologous Enzymes, Current Topics in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1568026611313050009
DOI https://dx.doi.org/10.2174/1568026611313050009 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery
Current Drug Targets Benzofuran Small Molecules as Potential Inhibitors of Human Protein Kinases. A Review
Current Pharmaceutical Design Yeast-Derived β-Glucan in Combination with Anti-Tumor Monoclonal Antibody Therapy in Cancer
Recent Patents on Anti-Cancer Drug Discovery Signal Transduction Therapy Targeting Apoptosis Pathways in Cancers
Current Signal Transduction Therapy Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities
Current Drug Targets Imaging of HER-2 Overexpression in Tumors for Guiding Therapy
Current Pharmaceutical Design Involvement of the Mitochondrial Benzodiazepine Receptor in Traumatic Brain Injury: Therapeutic Implications
CNS & Neurological Disorders - Drug Targets Bioaccessibility of Bioactive Compounds and Prebiotic Properties of Fruit and Vegetable By-products - A Mini Review
Current Bioactive Compounds Cytotoxic Effect of the Red Beetroot (Beta vulgaris L.) Extract Compared to Doxorubicin (Adriamycin) in the Human Prostate (PC-3) and Breast (MCF-7) Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Molecular Biological Roles of Ursolic Acid in the Treatment of Human Diseases
Current Bioactive Compounds CYP Epoxygenase Derived EETs: From Cardiovascular Protection to Human Cancer Therapy
Current Topics in Medicinal Chemistry A Cell Culture Model for the Assessment of the Chemopreventive Potential of Dietary Compounds.
Current Nutrition & Food Science Recent Development in Nano-Sized Dosage Forms of Plant Alkaloid Camptothecin-Derived Drugs
Recent Patents on Anti-Cancer Drug Discovery Deregulation of the Akt Pathway in Human Cancer
Current Cancer Drug Targets Combining Angiogenesis Inhibitors with Radiation: Advances and Challenges in Cancer Treatment
Current Pharmaceutical Design Targeted Therapy of Ovarian Cancer with Angiogenesis Inhibitors
Current Drug Targets Forms of Iron Binding in the Cells and the Chemical Features of Chelation Therapy
Mini-Reviews in Medicinal Chemistry Anti-Cancer Drug Discovery: Structure, Function and Novel Strategy – Part-3
Current Topics in Medicinal Chemistry Targeting Epigenetic Modifiers in Cancer
Current Medicinal Chemistry Nutraceuticals for Protection and Healing of Gastrointestinal Mucosa
Current Medicinal Chemistry