A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt

Title:A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt

Volume: 10 Issue: 3

Author(s): Rui Huang, Chunsong Xie, Lin Huang and Jinhua Liu

Affiliation:

Keywords: 1, 4, 7, 10-Tetraazacyclododecane, MRI, Tandem Reaction, Vinylsulfonium

Abstract: 1,4,7,10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1,4,7,10-Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.

Cite this article as:

Huang Rui, Xie Chunsong, Huang Lin and Liu Jinhua, A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt, Letters in Organic Chemistry 2013; 10 (3) . https://dx.doi.org/10.2174/1570178611310030009