The Synthesis of Enantiomers of 6-tert-Butyl-6-methylmorpholine-2,5- dione Using Wang Resin Supported Mukaiyama Reagent

Anna      Jakubowska; Joanna      Babiuch; Katarzyna      Kulig

doi:10.2174/1570178611310030002

Abstract

The synthesis of enantiomers of 6-tert-butyl-6-methylmorpholine-2,5-dione (3) using Wang resin supported 2- chloro- or 2-bromo- pyridinium triflate is described. The applied methodology could be considered as an interesting alternative to “classical” one and enables the synthesis of 6-tert-butyl-6-methylmorpholine-2,5-dione with higher yields and the isolation of product (3) is significantly easier.

Keywords: Wang resin supported Mukaiyama reagent, enantiomers of 6-tert-butyl-6-methylmorpholine-2, 5-dione, glycine equivalent.

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Letters in Organic Chemistry

Title:The Synthesis of Enantiomers of 6-tert-Butyl-6-methylmorpholine-2,5- dione Using Wang Resin Supported Mukaiyama Reagent

Volume: 10 Issue: 3

Author(s): Anna Jakubowska, Joanna Babiuch and Katarzyna Kulig

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Keywords: Wang resin supported Mukaiyama reagent, enantiomers of 6-tert-butyl-6-methylmorpholine-2, 5-dione, glycine equivalent.

Abstract: The synthesis of enantiomers of 6-tert-butyl-6-methylmorpholine-2,5-dione (3) using Wang resin supported 2- chloro- or 2-bromo- pyridinium triflate is described. The applied methodology could be considered as an interesting alternative to “classical” one and enables the synthesis of 6-tert-butyl-6-methylmorpholine-2,5-dione with higher yields and the isolation of product (3) is significantly easier.

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Jakubowska Anna, Babiuch Joanna and Kulig Katarzyna, The Synthesis of Enantiomers of 6-tert-Butyl-6-methylmorpholine-2,5- dione Using Wang Resin Supported Mukaiyama Reagent, Letters in Organic Chemistry 2013; 10 (3) . https://dx.doi.org/10.2174/1570178611310030002