Abstract
The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.
Keywords: Benzodiazepine, combinatorial synthesis, cyclic peptides, nitrogen heterocyclics, privileged structures, purines and pyrimidines, solid-phase synthesis.
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Current Computer-Aided Drug Design
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