Abstract
A convenient method was established for the synthesis of some new 6,7-dihydro-2-(methylthio)-5- aminopyrazolo[1,5-a]pyrimidine-3-carbonitriles 4 and -[1,2,4]triazolo[1,5-a]pyrimidin-5-amines 5 from β- cyanohydrazines 3 and suitable ketene dithioketals 2-[bis(methylthio)methylene]propanedinitrile 1 and dimethyl Ncyanocarbonimidodithioate 2, respectively in good yields. The structure of the title compound was characterized by IR, EA, 1H- and 13C-NMR.
Keywords: β-cyanohydrazines, ketene dithioketals, pyrazolopyrimidines, triazolopyrimidines
Letters in Organic Chemistry
Title:A Simple Access in One Step to Some New Substituted Pyrazolo- and [1,2,4]triazolo-[1,5-a]pyrimidines
Volume: 10 Issue: 2
Author(s): Monaem Balti, Khaireddine Dridi and Mohamed Lotfi El Efrit
Affiliation:
Keywords: β-cyanohydrazines, ketene dithioketals, pyrazolopyrimidines, triazolopyrimidines
Abstract: A convenient method was established for the synthesis of some new 6,7-dihydro-2-(methylthio)-5- aminopyrazolo[1,5-a]pyrimidine-3-carbonitriles 4 and -[1,2,4]triazolo[1,5-a]pyrimidin-5-amines 5 from β- cyanohydrazines 3 and suitable ketene dithioketals 2-[bis(methylthio)methylene]propanedinitrile 1 and dimethyl Ncyanocarbonimidodithioate 2, respectively in good yields. The structure of the title compound was characterized by IR, EA, 1H- and 13C-NMR.
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Cite this article as:
Balti Monaem, Dridi Khaireddine and Lotfi El Efrit Mohamed, A Simple Access in One Step to Some New Substituted Pyrazolo- and [1,2,4]triazolo-[1,5-a]pyrimidines, Letters in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570178611310020009
DOI https://dx.doi.org/10.2174/1570178611310020009 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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