Abstract
Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
Current Drug Targets
Title:Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review
Volume: 14 Issue: 4
Author(s): Sinoy Sugunan, Diya Binoy Joseph and G. K. Rajanikant
Affiliation:
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
Abstract: Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
Export Options
About this article
Cite this article as:
Sugunan Sinoy, Binoy Joseph Diya and K. Rajanikant G., Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review, Current Drug Targets 2013; 14 (4) . https://dx.doi.org/10.2174/1389450111314040011
DOI https://dx.doi.org/10.2174/1389450111314040011 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protein-Energy Malnutrition Alters Thermoregulatory Homeostasis and the Response to Brain Ischemia
Current Neurovascular Research Intracellular Drug Delivery: Mechanisms for Cell Entry
Current Pharmaceutical Design Oxidative Stress in Diabetic Nephropathy
Current Medicinal Chemistry Patent Selections
Recent Patents on Cardiovascular Drug Discovery Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Current Drug Targets Neuroprotective Effects of Heat Shock Protein70
CNS & Neurological Disorders - Drug Targets The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death
Current Medicinal Chemistry Crosstalk between Inflammation and the BBB in Stroke
Current Neuropharmacology Cerebral Artery Signal Transduction Mechanisms: Developmental Changes in Dynamics and Ca<sup>2+</sup> Sensitivity
Current Vascular Pharmacology Cerebrovascular Complications of Diabetes: Focus on Stroke
Endocrine, Metabolic & Immune Disorders - Drug Targets HspB5/αB-Crystallin: Properties and Current Progress in Neuropathy
Current Neurovascular Research Galectin-1 is a Novel Factor that Regulates Myotube Growth in Regenerating Skeletal Muscles
Current Drug Targets Benefits of L-Arginine on Cardiovascular System
Mini-Reviews in Medicinal Chemistry The Role of Oxidative Stress in Methamphetamine and MDMA-induced Toxicity
Mini-Reviews in Organic Chemistry In vivo Optical Molecular Imaging of Cardiovascular Diseases: Long Road Ahead
Current Molecular Imaging (Discontinued) A Novel Approach to the Old Issue of Ischemic Nephropathy
Current Vascular Pharmacology Future Treatment for COPD: Targeting Oxidative Stress and its Related Signal
Recent Patents on Inflammation & Allergy Drug Discovery Endothelial Progenitor Cells and Vascular Biology in Diabetes Mellitus: Current Knowledge and Future Perspectives
Current Diabetes Reviews Nitric Oxide-Derived Oxidants with a Focus on Peroxynitrite: Molecular Targets,Cellular Responses and Therapeutic Implications
Current Pharmaceutical Design Nuclear Factor κB and Adenosine Receptors: Biochemical and Behavioral Profiling
Current Neuropharmacology