Abstract
Proteins and peptides are the building blocks of human body and act as the arsenal to combat against the invading pathogenic organisms for treatment and management of diseases. Majority of such biomacromolecules are synthesized by the human body itself. However, entry of disease causing pathogens causes misleading in the synthesis of desired proteins for antibody formation. In such alarming situations, the delivery of requisite protein and peptide from external source helps in augmenting the body’s immunity. The major drawbacks underlying poor biopharmaceutical performance of high molecular weight protein and peptide drugs are due to poor oral absorption, formulation stability, degradation in the gastric milieu, susceptible to presystemic metabolism. Numerous literature recounts the application of myriad drug delivery strategies for the effective delivery of protein and peptides viz. parentral, oral, transdermal, nasal, pulmonary, rectal, buccal and ocular drug delivery systems. There are many reviews on various delivery strategies for protein and peptide pharmaceuticals, but the present review article provides a bird’s eye view on various novel drug delivery systems used for enhanced delivery of protein and peptide pharmaceuticals in the light of patent literature. Apart from this, the present manuscript endeavor provides idea on possible causes and major degradation pathways responsible for poor stability of protein and peptide drugs along with recent market instances on them utilizing novel drug delivery systems.
Keywords: Degradation pathways, delivery approaches, patents, stabilization
Recent Patents on Biotechnology
Title:Stabilization and Delivery Approaches for Protein and Peptide Pharmaceuticals: An Extensive Review of Patents
Volume: 7 Issue: 1
Author(s): Suryakanta Swain, Debanik Mondal, Sarwar Beg, Chinam Niranjan Patra, Subas Chandra Dinda, Jammula Sruti and Muddana Eswara Bhanoji Rao
Affiliation:
Keywords: Degradation pathways, delivery approaches, patents, stabilization
Abstract: Proteins and peptides are the building blocks of human body and act as the arsenal to combat against the invading pathogenic organisms for treatment and management of diseases. Majority of such biomacromolecules are synthesized by the human body itself. However, entry of disease causing pathogens causes misleading in the synthesis of desired proteins for antibody formation. In such alarming situations, the delivery of requisite protein and peptide from external source helps in augmenting the body’s immunity. The major drawbacks underlying poor biopharmaceutical performance of high molecular weight protein and peptide drugs are due to poor oral absorption, formulation stability, degradation in the gastric milieu, susceptible to presystemic metabolism. Numerous literature recounts the application of myriad drug delivery strategies for the effective delivery of protein and peptides viz. parentral, oral, transdermal, nasal, pulmonary, rectal, buccal and ocular drug delivery systems. There are many reviews on various delivery strategies for protein and peptide pharmaceuticals, but the present review article provides a bird’s eye view on various novel drug delivery systems used for enhanced delivery of protein and peptide pharmaceuticals in the light of patent literature. Apart from this, the present manuscript endeavor provides idea on possible causes and major degradation pathways responsible for poor stability of protein and peptide drugs along with recent market instances on them utilizing novel drug delivery systems.
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Cite this article as:
Swain Suryakanta, Mondal Debanik, Beg Sarwar, Niranjan Patra Chinam, Chandra Dinda Subas, Sruti Jammula and Eswara Bhanoji Rao Muddana, Stabilization and Delivery Approaches for Protein and Peptide Pharmaceuticals: An Extensive Review of Patents, Recent Patents on Biotechnology 2013; 7 (1) . https://dx.doi.org/10.2174/1872208311307010004
DOI https://dx.doi.org/10.2174/1872208311307010004 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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