A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists

Title:A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists

Volume: 13 Issue: 5

Author(s): Pooja S. Banerjee and Subir Samanta

Affiliation:

Keywords: Natural ligands, Pharmacophore, PPARγ, Synthetic ligands, Thiazolidinediones, Type II Diabetes

Abstract: Peroxisome Proliferator Activated Receptors gamma (PPARγ) are a class of ligand activated transcription factors with a prominent role in the regulation of metabolic processes. The present work aims towards examining the functional and structural features that facilitate the binding of small molecules based on Thiazolidinedione pharmacophore to PPARs. The intent of this article is to review all the reported thiazolidinediones and associated groups of PPARγ ligands.

Cite this article as:

S. Banerjee Pooja and Samanta Subir, A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists, Mini-Reviews in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1389557511313050007