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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Characterization of Clubbed Thiazolidin-4-one, Quinoline and Barbitone Derivatives as a Potent Antimicrobial Agents

Author(s): Nisheeth Chhotalal Desai, Hitesh Mansukhbhai Satodiya, Kiran Mavjibhai Rajpara, Vivek Vishnuprasad Joshi and Hasit Vinodray Vaghani

Volume 10, Issue 4, 2013

Page: [335 - 342] Pages: 8

DOI: 10.2174/1570180811310040007

Price: $65

Abstract

In the present investigation, it was of interest to synthesized some new derivatives of pyrimidine- 2,4,6(1H,3H,5H)-trione moiety incorporated with different biologically active pharmacophores such as thiazolidin-4- one, barbitone and 2-chloroquinoline-3-carbaldehyde. The structures of synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, and mass spectral data. Antimicrobial screening of title compounds were examined against Grampositive bacteria (Staphylococcus aureus and Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and three fungal species (Candida albicans, Aspergillus niger, and Aspergillus clavatus) by serial broth dilution method. Compounds 6b, 6e, 6f and 6h were associated with considerably higher antibacterial and antifungal activities.

Keywords: Barbitone, Quinoline, Thiazolidin-4-one


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