Abstract
In the last 20 years the practice of DNA sequence detection has gained more and more importance in a variety of fields like-genetics, food safety, pathology, and criminology. This has been driven by the growing knowledge about the human and other organisms genome. The development of sophisticated technologies for the analysis of DNA makes the analysis of DNA faster and easier to use, and enable numerous researchers to take advantage of these techniques in their scientific work. An interesting alternative for the standard fluorescence labelling of DNA are metal nanoparticles. This paper reviews different detection schemes for using metal nanoparticles, and especially gold nanoparticles, as labels in DNA analysis. It covers various methods for the detection of nanoparticle labels taking advantage of their unique optical properties. Alternative methods are also described using electromechanical, electrochemical and electrical methods for the detection.
Keywords: DNA detection, DNA microarrays, gold nanoparticles
Current Pharmaceutical Biotechnology
Title: Metal Nanoparticle-Based Detection for DNA Analysis
Volume: 8 Issue: 5
Author(s): Robert Moller and Wolfgang Fritzsche
Affiliation:
Keywords: DNA detection, DNA microarrays, gold nanoparticles
Abstract: In the last 20 years the practice of DNA sequence detection has gained more and more importance in a variety of fields like-genetics, food safety, pathology, and criminology. This has been driven by the growing knowledge about the human and other organisms genome. The development of sophisticated technologies for the analysis of DNA makes the analysis of DNA faster and easier to use, and enable numerous researchers to take advantage of these techniques in their scientific work. An interesting alternative for the standard fluorescence labelling of DNA are metal nanoparticles. This paper reviews different detection schemes for using metal nanoparticles, and especially gold nanoparticles, as labels in DNA analysis. It covers various methods for the detection of nanoparticle labels taking advantage of their unique optical properties. Alternative methods are also described using electromechanical, electrochemical and electrical methods for the detection.
Export Options
About this article
Cite this article as:
Moller Robert and Fritzsche Wolfgang, Metal Nanoparticle-Based Detection for DNA Analysis, Current Pharmaceutical Biotechnology 2007; 8 (5) . https://dx.doi.org/10.2174/138920107782109967
DOI https://dx.doi.org/10.2174/138920107782109967 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Proton Ion-Microbeam Elemental Analysis for Inhaled Particle-Induced Pulmonary Diseases: Application for Diagnosis and Assessment of Progression
Current Medicinal Chemistry MicroRNAs in Cancer: Small Molecules, Big Chances
Anti-Cancer Agents in Medicinal Chemistry Epigenetic Metalloenzymes
Current Medicinal Chemistry miR-1247 is Correlated with Prognosis of Pancreatic Cancer and Inhibits Cell Proliferation by Targeting Neuropilins
Current Molecular Medicine Recent Progress in Delivery of Therapeutic and Imaging Agents Utilizing Organic-Inorganic Hybrid Nanoparticles
Current Drug Delivery HIV-1 Vpr: A Closer Look at the Multifunctional Protein from the Structural Perspective
Current HIV Research Advances of Inorganic Materials in the Detection and Therapeutic Uses against Coronaviruses
Current Medicinal Chemistry Editorial (Hot Topic: Survival Signaling Through Focal Adhesion Kinase in Tumors)
Anti-Cancer Agents in Medicinal Chemistry Current Targets for Anticancer Drug Discovery
Current Drug Targets Mechanism of Drug Sensitivity and Resistance in Melanoma
Current Cancer Drug Targets Recent Developments of DNA Poisons - Human DNA Topoisomerase IIα Inhibitors - as Anticancer Agents
Current Pharmaceutical Design Gene Therapeutic Approaches for Immune Modulation in AIDS
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Current Concepts on Cardiovascular Stent Devices
Mini-Reviews in Medicinal Chemistry OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease
Current Immunology Reviews (Discontinued) Targeting the Eph System with Peptides and Peptide Conjugates
Current Drug Targets BRCA1-Associated Triple-Negative Breast Cancer and Potential Treatment for Ruthenium-Based Compounds
Current Cancer Drug Targets Medicinal Chemistry of Probimane and MST-16: Comparison of Anticancer Effects Between Bisdioxopiperazines
Medicinal Chemistry Rikkunshito and Ghrelin Secretion
Current Pharmaceutical Design Nitroimidazoles as Anti-Tumor Agents
Anti-Cancer Agents in Medicinal Chemistry Potential Uses of MicroRNA in Lung Cancer Diagnosis, Prognosis, and Therapy
Current Cancer Drug Targets