Smart Nanoengineered Polymeric Capsules as Ideal Pharmaceutical Carriers

Laura      Pastorino; Svetlana      Erokhina; Victor      Erokhin

doi:10.2174/138527213805289088

Abstract

An ideal drug must be absolutely inert in normal conditions, providing release of active compounds only in diseased areas. Nanoengineered polymeric capsules have required features. We describe here basic methods for the fabrication of such containers and give some particular examples of their use when the drug release is triggered by the presence of the disease itself or by the soft external action, with no side effects on the adjacent tissues.

Keywords: Ideal drug carrier, Layer-by-Layer electrostatic self-assembly, Polyelectrolyte capsules, Targeted drug delivery, Triggered drug release, Bacteriorhodopsin (BR), UV irradiation of azobenzene, Biocompatibilty, Confocal laser scanning microscopy (CLSM), Nanoengineered Polymeric Capsules