Abstract
Schizophrenia (SZ) is a severe neuropsychiatric disorder. A leading hypothesis is that SZ is a brain dysconnection syndrome, involving abnormal interactions between widespread brain networks. Resting state functional magnetic resonance imaging (R-fMRI) is a powerful tool to explore the dysconnectivity of brain networks in SZ and other disorders. Seed-based functional connectivity analysis, spatial independent component analysis (ICA), and graph theory-based analysis are popular methods to quantify brain network connectivity in R-fMRI data. Widespread network dysconnectivity in SZ has been observed using both seed-based analysis and ICA, although most seed-based studies report decreased connectivity while ICA studies report both increases and decreases. Importantly, most of the findings from both techniques are also associated with typical symptoms of the illness. Disrupted topological properties and altered modular community structure of brain system in SZ have been shown using graph theory-based analysis. Overall, the resting-state findings regarding brain networks deficits have advanced our understanding of the underlying pathology of SZ. In this article, we review aberrant brain connectivity networks in SZ measured in R-fMRI by the above approaches, and discuss future challenges.
Keywords: Schizophrenia, Resting state-fMRI, Dysconnectivity, Brain network, Seed-based, ICA, Graph.
Current Topics in Medicinal Chemistry
Title:Brain Connectivity Networks in Schizophrenia Underlying Resting State Functional Magnetic Resonance Imaging
Volume: 12 Issue: 21
Author(s): Qingbao Yu, Elena A. Allen, Jing Sui, Mohammad R. Arbabshirani, Godfrey Pearlson and Vince D. Calhoun
Affiliation:
Keywords: Schizophrenia, Resting state-fMRI, Dysconnectivity, Brain network, Seed-based, ICA, Graph.
Abstract: Schizophrenia (SZ) is a severe neuropsychiatric disorder. A leading hypothesis is that SZ is a brain dysconnection syndrome, involving abnormal interactions between widespread brain networks. Resting state functional magnetic resonance imaging (R-fMRI) is a powerful tool to explore the dysconnectivity of brain networks in SZ and other disorders. Seed-based functional connectivity analysis, spatial independent component analysis (ICA), and graph theory-based analysis are popular methods to quantify brain network connectivity in R-fMRI data. Widespread network dysconnectivity in SZ has been observed using both seed-based analysis and ICA, although most seed-based studies report decreased connectivity while ICA studies report both increases and decreases. Importantly, most of the findings from both techniques are also associated with typical symptoms of the illness. Disrupted topological properties and altered modular community structure of brain system in SZ have been shown using graph theory-based analysis. Overall, the resting-state findings regarding brain networks deficits have advanced our understanding of the underlying pathology of SZ. In this article, we review aberrant brain connectivity networks in SZ measured in R-fMRI by the above approaches, and discuss future challenges.
Export Options
About this article
Cite this article as:
Yu Qingbao, A. Allen Elena, Sui Jing, R. Arbabshirani Mohammad, Pearlson Godfrey and D. Calhoun Vince, Brain Connectivity Networks in Schizophrenia Underlying Resting State Functional Magnetic Resonance Imaging, Current Topics in Medicinal Chemistry 2012; 12 (21) . https://dx.doi.org/10.2174/1568026611212210012
DOI https://dx.doi.org/10.2174/1568026611212210012 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
BACE1 Levels Correlate with Phospho-Tau Levels in Human Cerebrospinal Fluid
Current Alzheimer Research Cardiovascular Effects of Hypoglycemic Agents in Diabetes Mellitus
Current Drug Safety MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders
Current Genomics Cholesterol Efflux and Reverse Cholesterol Transport: Experimental Approaches
Current Medicinal Chemistry Takotsubo Cardiomyopathy
Current Pharmaceutical Design Advances in Sickle Cell Disease Treatment: from Drug Discovery Until the Patient Monitoring
Cardiovascular & Hematological Agents in Medicinal Chemistry Oxidative Stress in HIV Patients Receiving Antiretroviral Therapy
Current HIV Research Treat to Target in Spondyloarthritis: The Time has Come
Current Rheumatology Reviews The Renin-Angiotensin System: Emerging Concepts
Current Hypertension Reviews Glucocorticoid Receptor Antagonists
Current Topics in Medicinal Chemistry Current Treatment of Autoimmune Blistering Diseases
Current Drug Discovery Technologies Metabolic-Inflammatory Changes, and Accelerated Atherosclerosis in HIV Patients: Rationale for Preventative Measures
Current Medicinal Chemistry Recent Patents in Diagnosis and Treatment for Inborn Errors of Metabolism
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Cellular Therapy for Heart Failure
Current Cardiology Reviews Chondroitin Sulfate and Sulfur Containing Chondroprotective Agents: Is there a Basis for their Pharmacological Action?
Current Rheumatology Reviews Telomerase Therapeutics for Degenerative Diseases
Current Molecular Medicine Regulation of Electrolyte Permeability by Herbal Monomers in Edematous Disorders
Current Pharmaceutical Design Leptin and Vascular Smooth Muscle Cells
Current Pharmaceutical Design The Role of Coagulation and Fibrinolysis in the Pathogenesis of Acute Lung Injury
Current Respiratory Medicine Reviews Serial Analysis of Gene Expression in Eukaryotic Pathogens
Infectious Disorders - Drug Targets