Amphetamine-Type Medicines: A Review of Pharmacokinetics, Pharmacodynamics, and Toxicological Aspects.

Title:Amphetamine-Type Medicines: A Review of Pharmacokinetics, Pharmacodynamics, and Toxicological Aspects.

Volume: 8 Issue: 4

Author(s): Kristianee C. Mariotti, Luciana G. Rossato, Pedro E. Fröehlich and Renata P. Limberger

Affiliation:

Keywords: Amphetamine, amphepramone, diethylpropione, fenproporex, methylphenidate, stimulants.

Abstract: Amphetamine-like drugs are sympathomimetic agents with marked central and peripheral stimulant properties. Despite the street illegal drugs such as amphetamine and ecstasy, some amphetamine-like compounds are also legally marketed under medical prescription in the treatment of attention deficit-hyperactivity disorder (methylphenidate) and obesity/overweight (fenproporex and diethylpropione). However, similar with what happens with their illicit analogues, therapeutic amphetamine-like drugs also share important toxicological risks. Although methylphenidate is considered the first choice in the treatment of attention deficit-hyperactivity disorder, its high popularity among teenagers and children is raising concern in the medical community. Regarding weight-loss purposes, the use of amphetamine-like compounds are very controversial, though. Thus, the present review will address pharmacokinetic, pharmacodynamic, and toxicological aspects of amphetamine-like compounds used with therapeutic aims.

Cite this article as:

Mariotti C. Kristianee, Rossato G. Luciana, Fröehlich E. Pedro and Limberger P. Renata, Amphetamine-Type Medicines: A Review of Pharmacokinetics, Pharmacodynamics, and Toxicological Aspects., Current Clinical Pharmacology 2013; 8 (4) . https://dx.doi.org/10.2174/15748847113089990052