Abstract
Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.
Keywords: Inflammation, myocardial injury, ischemia-reperfusion
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation
Volume: 12 Issue: 1
Author(s): Anne Vincent, Benoit Lattuca, Nolwenn Merlet, Catherine Sportouch-Dukhan and Stephanie Barrere-Lemaire
Affiliation:
Keywords: Inflammation, myocardial injury, ischemia-reperfusion
Abstract: Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.
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Cite this article as:
Vincent Anne, Lattuca Benoit, Merlet Nolwenn, Sportouch-Dukhan Catherine and Barrere-Lemaire Stephanie, New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2013; 12 (1) . https://dx.doi.org/10.2174/1871523011312010007
DOI https://dx.doi.org/10.2174/1871523011312010007 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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