Abstract
Atherosclerosis is characterized by chronic inflammation of the vascular wall. Macrophages, which differentiate from circulating monocytes, give rise to foam cells by excessive accumulation of modified lipoproteins. Atherogenesis subsequently progresses through necrotic core expansion associated with apoptosis and the suppressed clearance of apoptotic macrophage (i.e. efferocytosis), followed by the transition to vulnerable plaques. The vulnerable plaque is characterized by thinning of the fibrous cap and necrotic core expansion. Here, the impact of monocytes/macrophages in both early atherogenesis and advanced plaque progression is discussed with a focus on the potential targeting of inflammatory processes in atherosclerosis.
Keywords: Atherosclerosis, inflammation, vulnerable plaque, chemokines, cytokines, oxidative stress, macrophages, lipoproteins, efferocytosis, fibrous cap
Current Pharmaceutical Design
Title:Novel Strategies to Target Inflammatory Processes in Atherosclerosis
Volume: 19 Issue: 9
Author(s): Toshio Imanishi and Takashi Akasaka
Affiliation:
Keywords: Atherosclerosis, inflammation, vulnerable plaque, chemokines, cytokines, oxidative stress, macrophages, lipoproteins, efferocytosis, fibrous cap
Abstract: Atherosclerosis is characterized by chronic inflammation of the vascular wall. Macrophages, which differentiate from circulating monocytes, give rise to foam cells by excessive accumulation of modified lipoproteins. Atherogenesis subsequently progresses through necrotic core expansion associated with apoptosis and the suppressed clearance of apoptotic macrophage (i.e. efferocytosis), followed by the transition to vulnerable plaques. The vulnerable plaque is characterized by thinning of the fibrous cap and necrotic core expansion. Here, the impact of monocytes/macrophages in both early atherogenesis and advanced plaque progression is discussed with a focus on the potential targeting of inflammatory processes in atherosclerosis.
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Cite this article as:
Imanishi Toshio and Akasaka Takashi, Novel Strategies to Target Inflammatory Processes in Atherosclerosis, Current Pharmaceutical Design 2013; 19 (9) . https://dx.doi.org/10.2174/1381612811319090009
DOI https://dx.doi.org/10.2174/1381612811319090009 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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