Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

Title:Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

Volume: 13 Issue: 8

Author(s): Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska, Anne-Sophie Delattre and Rob Lavigne

Affiliation:

Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis

Abstract: The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.

Cite this article as:

Drulis-Kawa Zuzanna, Majkowska-Skrobek Grazyna, Maciejewska Barbara, Delattre Anne-Sophie and Lavigne Rob, Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications, Current Protein & Peptide Science 2012; 13 (8) . https://dx.doi.org/10.2174/138920312804871193

DOI https://dx.doi.org/10.2174/138920312804871193	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550