Abstract
The kidney is a major organ for drug elimination. The function of the neonatal kidney is markedly immature with a reduction of renal blood flow, of glomerular filtration and of active tubular secretion, even in healthy, term infants. Maturation of renal function in particular of glomerular filtration rate is gestational age and postnatal age-dependant. Moreover, many neonatal pathological conditions such as preterm birth, sepsis or perinatal asphyxia can also affect renal function. These developmental changes have a major impact on drug metabolism and elimination. Alterations in renal clearance can influence significantly both drugs efficacy and toxicity. Moreover, nephrogenesis is a still ongoing process in a number of premature infants before 36 wks postconceptional age. Drugs and toxic factors that may alter the constitution of the congenital nephron number endowment during this period may have long term consequences on arterial pressure and renal function at adulthood.
Keywords: Drug elimination, glomerular filtration, neonatal kidney, renal clearance, tubular secretion, Neonatal Kidney, Drug, Metabolism, Elimination, Metanephros, RBF, Juxtamedullary, Angiotensin II, COX
Current Drug Metabolism
Title:The Neonatal Kidney: Implications for Drug Metabolism and Elimination
Volume: 14 Issue: 2
Author(s): I. Ligi, F. Boubred, I. Grandvuillemin and U. Simeoni
Affiliation:
Keywords: Drug elimination, glomerular filtration, neonatal kidney, renal clearance, tubular secretion, Neonatal Kidney, Drug, Metabolism, Elimination, Metanephros, RBF, Juxtamedullary, Angiotensin II, COX
Abstract: The kidney is a major organ for drug elimination. The function of the neonatal kidney is markedly immature with a reduction of renal blood flow, of glomerular filtration and of active tubular secretion, even in healthy, term infants. Maturation of renal function in particular of glomerular filtration rate is gestational age and postnatal age-dependant. Moreover, many neonatal pathological conditions such as preterm birth, sepsis or perinatal asphyxia can also affect renal function. These developmental changes have a major impact on drug metabolism and elimination. Alterations in renal clearance can influence significantly both drugs efficacy and toxicity. Moreover, nephrogenesis is a still ongoing process in a number of premature infants before 36 wks postconceptional age. Drugs and toxic factors that may alter the constitution of the congenital nephron number endowment during this period may have long term consequences on arterial pressure and renal function at adulthood.
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Cite this article as:
Ligi I., Boubred F., Grandvuillemin I. and Simeoni U., The Neonatal Kidney: Implications for Drug Metabolism and Elimination, Current Drug Metabolism 2013; 14 (2) . https://dx.doi.org/10.2174/1389200211314020004
DOI https://dx.doi.org/10.2174/1389200211314020004 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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