Abstract
Cervical cancer is a major health problem and almost all of these cancers are related to a high risk Human Papillomavirus cervical infection.
The Human Papillomavirus transforming potential has long been probed and is mainly characterized by the integration of the virus in the host genomes and the expression of the viral oncoproteins such as the E6 and E7 mRNAs. The vast majority of the HPV infections are transient and resolve and just a few percentages of patients are noted to develop a persistent infection. Therefore, there is the need of identifying appropriate biomarkers that can predict and differentiate transient vs persistent and clinical relevant HPV cervical infections.
To date, two categories of commercial assays have been introduced, mainly aiming to the detection of the E6 and E7 mRNAs and of the surrogates of the E7 activity (p16ink4A protein).
The aim of the present study is to analyse the basis of the HPV-related carcinogenesis and to discuss the commercial biomarkers developed to-date, reviewing those studies that used the above-mentioned assays in a clinical setting.
Keywords: HPV, E6, E7, p16, molecular test, cervical cancer, viral oncoproteins, mRNAs, p16ink4A protein, biomarkers
Current Pharmaceutical Design
Title:HPV Infections: Basis of Neoplastic Transformation and Related Molecular Tests
Volume: 19 Issue: 8
Author(s): Deborah French and Laura Lorenzon
Affiliation:
Keywords: HPV, E6, E7, p16, molecular test, cervical cancer, viral oncoproteins, mRNAs, p16ink4A protein, biomarkers
Abstract: Cervical cancer is a major health problem and almost all of these cancers are related to a high risk Human Papillomavirus cervical infection.
The Human Papillomavirus transforming potential has long been probed and is mainly characterized by the integration of the virus in the host genomes and the expression of the viral oncoproteins such as the E6 and E7 mRNAs. The vast majority of the HPV infections are transient and resolve and just a few percentages of patients are noted to develop a persistent infection. Therefore, there is the need of identifying appropriate biomarkers that can predict and differentiate transient vs persistent and clinical relevant HPV cervical infections.
To date, two categories of commercial assays have been introduced, mainly aiming to the detection of the E6 and E7 mRNAs and of the surrogates of the E7 activity (p16ink4A protein).
The aim of the present study is to analyse the basis of the HPV-related carcinogenesis and to discuss the commercial biomarkers developed to-date, reviewing those studies that used the above-mentioned assays in a clinical setting.
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Cite this article as:
French Deborah and Lorenzon Laura, HPV Infections: Basis of Neoplastic Transformation and Related Molecular Tests, Current Pharmaceutical Design 2013; 19 (8) . https://dx.doi.org/10.2174/1381612811319080003
DOI https://dx.doi.org/10.2174/1381612811319080003 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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