Synthesis of Quinazolinone Conjugated Shorter Analogues of Bactenecin7 as Potent Antimicrobials

Title:Synthesis of Quinazolinone Conjugated Shorter Analogues of Bactenecin7 as Potent Antimicrobials

Volume: 20 Issue: 2

Author(s): R. Suhas, S. Chandrashekar, S. M. Anil and D. Channe Gowda

Affiliation:

Keywords: Quinazolinone. bactenecin7. conjugation. potent antimicrobials

Abstract: A series of shorter peptide analogues of Bactenecin7 (RP, PRP, GPRP and RPRP) were synthesized and conjugated to 3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid to study the effect of conjugation. All the peptides and their conjugates were characterized by analytical and spectroscopic techniques. The synthesized compounds viz., peptides, heterocyclic conjugates and the hydrogenolyzed products were evaluated for antimicrobial activity against a panel of pathogens. The results revealed that all the conjugates have shown enhanced activity than their counterparts. Further, hydrogenolyzed tetrapeptide conjugates (10 and 13) have exerted highly potent activity nearly 3-4 times than the standard drugs used.

Cite this article as:

Suhas R., Chandrashekar S., M. Anil S. and Channe Gowda D., Synthesis of Quinazolinone Conjugated Shorter Analogues of Bactenecin7 as Potent Antimicrobials, Protein & Peptide Letters 2013; 20 (2) . https://dx.doi.org/10.2174/0929866511320020005

DOI https://dx.doi.org/10.2174/0929866511320020005	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305