Abstract
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
Keywords: Andrographolide, Derivatives, Anti-HIV, C8166 cells, Natural products, Synthesis, Acquired immune deficiency syndrome, human immunodeficiency virus, RDCSY- I capillary apparatus, lymphocyte counts
Letters in Drug Design & Discovery
Title:Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
Volume: 10 Issue: 2
Author(s): Guolong Gu, Haiyan Lin, Yajuan Liu, Liumeng Yang, Yongtang Zheng, Bin Wang, Chunlei Tang, Hai Qian and Wenlong Huang
Affiliation:
Keywords: Andrographolide, Derivatives, Anti-HIV, C8166 cells, Natural products, Synthesis, Acquired immune deficiency syndrome, human immunodeficiency virus, RDCSY- I capillary apparatus, lymphocyte counts
Abstract: A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
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Cite this article as:
Gu Guolong, Lin Haiyan, Liu Yajuan, Yang Liumeng, Zheng Yongtang, Wang Bin, Tang Chunlei, Qian Hai and Huang Wenlong, Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives, Letters in Drug Design & Discovery 2013; 10 (2) . https://dx.doi.org/10.2174/157018013804725107
DOI https://dx.doi.org/10.2174/157018013804725107 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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