Abstract
Recent studies of the platelet transcriptome have shown it to be complex and readily analysed by modern techniques. Among the thousands of distinct transcripts are many not previously described in platelets. Differences in message abundance between groups are apparent, and these are reflected at the protein level. Platelets are enriched in messages for receptors, signal transduction proteins and cytokines. Categories of potential drug targets include novel receptors mediating platelet activation and proteins involved in signal transduction. In addition, proteins released or secreted by activated platelets, or specifically translated from mRNA following platelet activation represent a new category of potential drug target for the treatment and prevention of thrombosis and atherogenesis. Transcriptional studies provides a means for the identification and characterisation of novel platelet drug targets in all these categories.
Keywords: Platelet RNA, Spotted Oligonucleotide Array, Affymetrix U95 Array, Translated Proteins, platelet-specific targets
Current Pharmaceutical Design
Title: Finding Drug Targets Through Analysis of the Platelet Transcriptome
Volume: 13 Issue: 26
Author(s): James McRedmond
Affiliation:
Keywords: Platelet RNA, Spotted Oligonucleotide Array, Affymetrix U95 Array, Translated Proteins, platelet-specific targets
Abstract: Recent studies of the platelet transcriptome have shown it to be complex and readily analysed by modern techniques. Among the thousands of distinct transcripts are many not previously described in platelets. Differences in message abundance between groups are apparent, and these are reflected at the protein level. Platelets are enriched in messages for receptors, signal transduction proteins and cytokines. Categories of potential drug targets include novel receptors mediating platelet activation and proteins involved in signal transduction. In addition, proteins released or secreted by activated platelets, or specifically translated from mRNA following platelet activation represent a new category of potential drug target for the treatment and prevention of thrombosis and atherogenesis. Transcriptional studies provides a means for the identification and characterisation of novel platelet drug targets in all these categories.
Export Options
About this article
Cite this article as:
McRedmond James, Finding Drug Targets Through Analysis of the Platelet Transcriptome, Current Pharmaceutical Design 2007; 13 (26) . https://dx.doi.org/10.2174/138161207781662993
DOI https://dx.doi.org/10.2174/138161207781662993 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
TGF-β Signaling in Gastrointestinal Cancer Stem Cells
Current Cancer Therapy Reviews Mouse Induced Glioma-Initiating Cell Models and Therapeutic Targets
Anti-Cancer Agents in Medicinal Chemistry Polymorphisms of Human N-Acetyltransferases and Cancer Risk
Current Drug Metabolism Modulating Mitochondria-Mediated Apoptotic Cell Death through Targeting of Bcl-2 Family Proteins
Recent Patents on DNA & Gene Sequences Hemolytic Uremic Syndrome in Children
Current Pediatric Reviews The Protease of Human T-Cell Leukemia Virus Type-1 is a Potential Therapeutic Target
Current Pharmaceutical Design Effects of Anticancer Drugs in Reproductive Parameters of Juvenile Male Animals and Role of Protective Agents
Anti-Cancer Agents in Medicinal Chemistry Characterizing the Relationship Between the Chemical Structures of Drugs and their Activities on Primary Cultures of Pediatric Solid Tumors
Current Medicinal Chemistry HPLC-NMR Chemical Profiling of the Australian Carnivorous Plant, Drosera erythrohiza subspecies magna
The Natural Products Journal Cytotoxic Activity of Polysubstituted 7-chloro-4-quinolinylhydrazone Derivatives
Letters in Drug Design & Discovery New Strategies in the Discovery of Novel Non-Camptothecin Topoisomerase I Inhibitors
Current Medicinal Chemistry Biological Applications of the Receptor Mimetic Peptide Mastoparan
Current Protein & Peptide Science Animal Models of Atherosclerosis Progression: Current Concepts
Current Drug Targets - Cardiovascular & Hematological Disorders Palifermin in theManagement of Mucositis in Hematological Malignancies: Current Evidences and Future Perspectives
Cardiovascular & Hematological Agents in Medicinal Chemistry Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent
Current Cancer Drug Targets Editorial from Guest Editor [Hot Topic:Vitamin D and Respiratory Health (Guest Editor: Adrian R. Martineau)]
Current Respiratory Medicine Reviews Editorial: Looking Forward to Another Successful Year
Current Cancer Drug Targets Nucleic Acids as Therapeutic Agents
Current Topics in Medicinal Chemistry Myelodysplastic/Myeloproliferative Neoplasms
Current Cancer Therapy Reviews Gene Therapy for Pituitary Tumors
Current Gene Therapy