Recent Advances in the Characterisation of the Platelet Membrane System by Proteomics

M.      Foy; P.   B.   Maguire

doi:10.2174/138161207781662911

Abstract

Platelets are the principle effectors of cellular haemostasis and key mediators in the pathogenesis of thrombosis. A variety of membrane receptors determine platelet reactivity with numerous agonists and adhesive proteins, and therefore represent key targets for the development of antiplatelet drug therapy. Here, we summarise recent advances in the analysis of the complex platelet membrane system achieved through the integration of platelet biology and proteomics.

Keywords: Platelet, membrane, receptors, lipid raft, proteomics, mass spectrometry

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Current Pharmaceutical Design

Title: Recent Advances in the Characterisation of the Platelet Membrane System by Proteomics

Volume: 13 Issue: 26

Author(s): M. Foy and P. B. Maguire

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Keywords: Platelet, membrane, receptors, lipid raft, proteomics, mass spectrometry

Abstract: Platelets are the principle effectors of cellular haemostasis and key mediators in the pathogenesis of thrombosis. A variety of membrane receptors determine platelet reactivity with numerous agonists and adhesive proteins, and therefore represent key targets for the development of antiplatelet drug therapy. Here, we summarise recent advances in the analysis of the complex platelet membrane system achieved through the integration of platelet biology and proteomics.

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Foy M. and Maguire B. P., Recent Advances in the Characterisation of the Platelet Membrane System by Proteomics, Current Pharmaceutical Design 2007; 13 (26) . https://dx.doi.org/10.2174/138161207781662911