Design, Synthesis and Antimicrobial Properties of Novel 3,3a,4,5,6,7- Hexahydroindazole and Arylthiazolylpyrazoline Derivatives

Title:Design, Synthesis and Antimicrobial Properties of Novel 3,3a,4,5,6,7- Hexahydroindazole and Arylthiazolylpyrazoline Derivatives

Volume: 9 Issue: 1

Author(s): Abha Bishnoi, Suruchi Singh, Anil K. Tiwari, Arun Sethi and Chandrakant Mani Tripathi

Affiliation:

Keywords: Antibacterial Activity, Antifungal Activity, Arylthiazolylpyrazoline, Cyclization, Diastereoselectivity, Heterocycles

Abstract: A remarkable diastereoselective synthesis of some novel arylthiazolyl pyrazoline derivatives 3(a-l) is displayed which were evaluated for their in vitro antimicrobial activities. In particular, compounds 3e, 3g & 3l (MIC 12.5µg /ml) showed good activity against S. aureus and compounds 3b & 3j (MIC 12.5 µg / ml) against B. subtilis. Compounds 3g, 3i, 3j (MIC 12.5 µg/ ml) and 3l (MIC 6.25 µg / ml) also displayed excellent antifungal activity against C. albicans. Of all the synthesized compounds, 3g and 3e exerted a wide range of antibacterial activities against entire tested gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacterial strain except P. aeruginosa.

Cite this article as:

Bishnoi Abha, Singh Suruchi, K. Tiwari Anil, Sethi Arun and Mani Tripathi Chandrakant, Design, Synthesis and Antimicrobial Properties of Novel 3,3a,4,5,6,7- Hexahydroindazole and Arylthiazolylpyrazoline Derivatives, Medicinal Chemistry 2013; 9 (1) . https://dx.doi.org/10.2174/1573406411309010045