Abstract
A remarkable diastereoselective synthesis of some novel arylthiazolyl pyrazoline derivatives 3(a-l) is displayed which were evaluated for their in vitro antimicrobial activities. In particular, compounds 3e, 3g & 3l (MIC 12.5µg /ml) showed good activity against S. aureus and compounds 3b & 3j (MIC 12.5 µg / ml) against B. subtilis. Compounds 3g, 3i, 3j (MIC 12.5 µg/ ml) and 3l (MIC 6.25 µg / ml) also displayed excellent antifungal activity against C. albicans. Of all the synthesized compounds, 3g and 3e exerted a wide range of antibacterial activities against entire tested gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacterial strain except P. aeruginosa.
Keywords: Antibacterial Activity, Antifungal Activity, Arylthiazolylpyrazoline, Cyclization, Diastereoselectivity, Heterocycles
Medicinal Chemistry
Title:Design, Synthesis and Antimicrobial Properties of Novel 3,3a,4,5,6,7- Hexahydroindazole and Arylthiazolylpyrazoline Derivatives
Volume: 9 Issue: 1
Author(s): Abha Bishnoi, Suruchi Singh, Anil K. Tiwari, Arun Sethi and Chandrakant Mani Tripathi
Affiliation:
Keywords: Antibacterial Activity, Antifungal Activity, Arylthiazolylpyrazoline, Cyclization, Diastereoselectivity, Heterocycles
Abstract: A remarkable diastereoselective synthesis of some novel arylthiazolyl pyrazoline derivatives 3(a-l) is displayed which were evaluated for their in vitro antimicrobial activities. In particular, compounds 3e, 3g & 3l (MIC 12.5µg /ml) showed good activity against S. aureus and compounds 3b & 3j (MIC 12.5 µg / ml) against B. subtilis. Compounds 3g, 3i, 3j (MIC 12.5 µg/ ml) and 3l (MIC 6.25 µg / ml) also displayed excellent antifungal activity against C. albicans. Of all the synthesized compounds, 3g and 3e exerted a wide range of antibacterial activities against entire tested gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacterial strain except P. aeruginosa.
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Cite this article as:
Bishnoi Abha, Singh Suruchi, K. Tiwari Anil, Sethi Arun and Mani Tripathi Chandrakant, Design, Synthesis and Antimicrobial Properties of Novel 3,3a,4,5,6,7- Hexahydroindazole and Arylthiazolylpyrazoline Derivatives, Medicinal Chemistry 2013; 9 (1) . https://dx.doi.org/10.2174/1573406411309010045
DOI https://dx.doi.org/10.2174/1573406411309010045 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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