Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Title:Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Volume: 10 Issue: 4

Author(s): Peter Kovacic and Ratnasamy Somanathan

Affiliation:

Keywords: Redox, neurodegenerative diseases, reactive oxygen species, oxidative stress

Abstract: Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.

Cite this article as:

Kovacic Peter and Somanathan Ratnasamy, Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species, Current Neuropharmacology 2012; 10 (4) . https://dx.doi.org/10.2174/1570159X11209040289