Abstract
Surgery is the single most effective therapy for patients with solid tumors. However, up to half of the patients who receive surgical resection will relapse from their cancer. Despite the significant benefit from surgery, there is a growing body of evidence that suggests that surgery may also contribute to tumor recurrence. The evidence supporting this claim can be divided into immunologic and non-immunologic mechanisms. The non-immunologic mechanisms associated with surgery include direct seeding through tissue manipulation, pressure activation of malignant cells, the release of angiogenic factors, and an increase in circulating growth factors. Surgery also has dramatic implications for the immune system; these include the suppression of cell-mediated immunity, the activation of the neuroendocrine response, and anesthesia related immunosuppression. The factors associated with post-surgical tumor recurrence are complex; nevertheless, a better understanding of these mechanisms provides an opportunity to develop therapeutic interventions that can lower the recurrence rate in patients with solid tumors.
Keywords: Cell mediated immunity, Immunosuppression, Mechanical seeding, Tumor recurrence
Current Cancer Therapy Reviews
Title:“Letting the Air In” Can Set the Stage for Tumor Recurrences
Volume: 8 Issue: 4
Author(s): Benjamin A. Laguna, Zachary C. G. Tucker, Horace DeLisser and Sunil Singhal
Affiliation:
Keywords: Cell mediated immunity, Immunosuppression, Mechanical seeding, Tumor recurrence
Abstract: Surgery is the single most effective therapy for patients with solid tumors. However, up to half of the patients who receive surgical resection will relapse from their cancer. Despite the significant benefit from surgery, there is a growing body of evidence that suggests that surgery may also contribute to tumor recurrence. The evidence supporting this claim can be divided into immunologic and non-immunologic mechanisms. The non-immunologic mechanisms associated with surgery include direct seeding through tissue manipulation, pressure activation of malignant cells, the release of angiogenic factors, and an increase in circulating growth factors. Surgery also has dramatic implications for the immune system; these include the suppression of cell-mediated immunity, the activation of the neuroendocrine response, and anesthesia related immunosuppression. The factors associated with post-surgical tumor recurrence are complex; nevertheless, a better understanding of these mechanisms provides an opportunity to develop therapeutic interventions that can lower the recurrence rate in patients with solid tumors.
Export Options
About this article
Cite this article as:
A. Laguna Benjamin, C. G. Tucker Zachary, DeLisser Horace and Singhal Sunil, “Letting the Air In” Can Set the Stage for Tumor Recurrences, Current Cancer Therapy Reviews 2012; 8 (4) . https://dx.doi.org/10.2174/1573394711208040293
DOI https://dx.doi.org/10.2174/1573394711208040293 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-IL-13 in Inflammatory Bowel Disease: From the Bench to the Bedside
Current Drug Targets Osteopontin; as a Target Molecule for the Treatment of Inflammatory Diseases
Current Drug Targets Metastatic Gastro-intestinal Neuroendocrine Tumors: A Case Report of Real Life Management Challenges and Success
Current Cancer Therapy Reviews New Drug Delivery Systems in Inflammatory Bowel Disease: MMX™ and Tailored Delivery to the Gut
Current Medicinal Chemistry Biotechnological Approaches for the Treatment of Inflammatory Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target
Current Cancer Therapy Reviews Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents
Current Medicinal Chemistry Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones
Medicinal Chemistry Vitamin-D in the Immune System: Genomic and Non-Genomic Actions
Mini-Reviews in Medicinal Chemistry Drug Evolution Concept in Drug Design: 2. Chimera Method
Medicinal Chemistry Breakfast and Learning: An Updated Review
Current Nutrition & Food Science Peroxisome Proliferator-Activated Receptors: The Nutritionally Controlled Molecular Networks that Integrate Inflammation, Immunity and Metabolism
Current Nutrition & Food Science Vitamin D : Autoimmunity and Gender
Current Medicinal Chemistry Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
Recent Patents on Anti-Cancer Drug Discovery Complications Following Stem Cell Therapy in Inflammatory Bowel Disease
Current Stem Cell Research & Therapy Integrin Antagonists: A Special Emphasis on Structural Requirements of N-benzoyl-L-biphenylalanines as α4β7 and α4β1 Antagonists
Current Signal Transduction Therapy Destroying RNA as a Therapeutic Approach
Current Medicinal Chemistry Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease
Current Drug Metabolism Pituitary Adenylate Cyclase Activating Polypeptide: A Potential Neuroprotective Peptide
Current Pharmaceutical Design Ginger and Heart Health: From Mechanisms to Therapeutics
Current Molecular Pharmacology