Abstract
Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.
Keywords: Cascade reaction, multicomponent reaction, one-pot synthesis, tandem reaction, telescoping.
Current Organic Synthesis
Title:One-pot Synthesis and its Practical Application in Pharmaceutical Industry
Volume: 9 Issue: 6
Author(s): Wenyi Zhao and Fen-Er Chen
Affiliation:
Keywords: Cascade reaction, multicomponent reaction, one-pot synthesis, tandem reaction, telescoping.
Abstract: Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.
Export Options
About this article
Cite this article as:
Zhao Wenyi and Chen Fen-Er, One-pot Synthesis and its Practical Application in Pharmaceutical Industry, Current Organic Synthesis 2012; 9 (6) . https://dx.doi.org/10.2174/157017912803901619
DOI https://dx.doi.org/10.2174/157017912803901619 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Progress in Topical siRNA Delivery Approaches for Skin Disorders
Current Pharmaceutical Design From Amino Acids to Proteins as Targets for Metal-based Drugs
Current Drug Metabolism Epidemiology and Pathology of Malignant Mesothelioma
Current Respiratory Medicine Reviews Pleural Fluid Analysis for Evaluating Pleural Effusions
Current Respiratory Medicine Reviews Epigenetic Aberrations and Targeted Epigenetic Therapy of Esophageal Cancer
Current Cancer Drug Targets Role of NF-κB and NF-κB-regulated Gene Products in Chemoresistance and Radioresistance
Current Cancer Therapy Reviews Incidental Extracardiac Findings on Coronary Computed Tomography Angiography: A Pictorial Review of Imaging Findings
Current Medical Imaging The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib
Current Pharmaceutical Design Novel Biomarkers Assessing the Calcium Deposition in Coronary Artery Disease
Current Medicinal Chemistry Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival
Current Protein & Peptide Science Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity
Current Medicinal Chemistry Cytokine Network: New Targeted Therapy for Pancreatic Cancer
Current Pharmaceutical Design Selectively Replicating Adenoviruses for Oncolytic Therapy
Current Cancer Drug Targets Is the Vascular System a Main Target for Thyroid Hormones? From Molecular and Biochemical Findings to Clinical Perspectives
Current Vascular Pharmacology Farnesylated Proteins as Anticancer Drug Targets: From Laboratory to the Clinic
Current Medicinal Chemistry - Anti-Cancer Agents Intraperitoneal Oncolytic and Tumor Vaccination Therapy with Replication-Competent Recombinant Virus: The Herpes Paradigm
Current Gene Therapy A Review of Natural and Synthetic Antioxidants Important for Health and Longevity
Current Medicinal Chemistry Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals
Current Drug Targets Poly (ADP-Ribosyl) Polymerase 1 Inhibitors: A Patent Review
Recent Patents on Anti-Cancer Drug Discovery T Cell Replicative Senescence in Human Aging
Current Pharmaceutical Design