Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry

Lina      Guo; Yue      Wan; Xin      Wang; Peng      George Wang; Wei      Zhao

doi:10.2174/138955712803832672

Abstract

With the development of glycomics, more and more carbohydrate mimetics were used to investigate the interactions between carbohydrate-proteins, especially in physiological and pathological processes, molecular recognition, signal transduction, cell communication, cell differentiation and developmental events. Recently, because of the drugresistance of microorganisms and the development of antibiotics, the interactions between carbohydrate mimetics and RNAs are becoming hot issue. Aminoglycosides, one family of important antibiotics, can bind with 30S subunits of rRNA to prevent the normal translations of proteins, inhibit the proteins involving in the drug-resistance. In this review, the latest advances in development and applications of aminoglycosides are summarized and the detailed descriptions on the SAR study (Structure-activity relationship) of aminoglycoside derivatives are discussed.

Keywords: Carbohydrate mimetic, aminoglycoside antibiotics, rRNA, structure-activity relationship, enzymatic modification, inhibitor, glycochemistry, Diaminocyclitols, Mycobacterium