Abstract
The revision of the structures and properties of Calystegines shows that they can be regarded as carbohydrate mimics, with related biological activities and peculiar characteristics. Not only they can be isolated from food plants, but they can be obtained from a variety of monosaccharide derivatives and of non-carbohydrate products. Although several synthetic calystegine analogs have been reported as glycosidase inhibitors, new, more potent and effective inhibitors are required.
Keywords: Calystegine, Polydroxylated Nortropane, Polydroxylated Alkaloid, Glycosidase Inhibitor, dihydroxynortropanes, hemiaminal, biogenetic, pyrrolidines
Mini-Reviews in Medicinal Chemistry
Title:Advances in the Synthesis of Calystegines and Related Products and their Biochemical Properties
Volume: 12 Issue: 14
Author(s): M.S. Pino-Gonzalez, N. Ona and A. Romero-Carrasco
Affiliation:
Keywords: Calystegine, Polydroxylated Nortropane, Polydroxylated Alkaloid, Glycosidase Inhibitor, dihydroxynortropanes, hemiaminal, biogenetic, pyrrolidines
Abstract: The revision of the structures and properties of Calystegines shows that they can be regarded as carbohydrate mimics, with related biological activities and peculiar characteristics. Not only they can be isolated from food plants, but they can be obtained from a variety of monosaccharide derivatives and of non-carbohydrate products. Although several synthetic calystegine analogs have been reported as glycosidase inhibitors, new, more potent and effective inhibitors are required.
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Cite this article as:
Pino-Gonzalez M.S., Ona N. and Romero-Carrasco A., Advances in the Synthesis of Calystegines and Related Products and their Biochemical Properties, Mini-Reviews in Medicinal Chemistry 2012; 12 (14) . https://dx.doi.org/10.2174/138955712803832708
DOI https://dx.doi.org/10.2174/138955712803832708 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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