Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles

Title:Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles

Volume: 9 Issue: 10

Author(s): M. Siva Nagi Reddy, B. Sailaja Kumari and B. Hari Babu

Affiliation:

Keywords: 5-chlorosalicylaldehyde, Oxadiazoles, Cytotoxicity, Brine shrimp, Chromene derivatives, Synthesis, tyrosine kinase inhibitors, anti-inflammatory agents, Chromene derivatives, cytotoxicity properties

Abstract: Novel 3,5-disubstituted 1,2,4-oxadiazoles 4a-4j were prepared from commercially available chlorosalicylaldehyde and screened for their cytotoxicity properties using brine shrimp (Artemia salina) bioassay and compared with the standard podophyllotoxin. The oxadiazoles 4a, 4c, 4e and 4h exhibited cytotoxicity activity in the series.

Cite this article as:

Siva Nagi Reddy M., Sailaja Kumari B. and Hari Babu B., Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles, Letters in Drug Design & Discovery 2012; 9 (10) . https://dx.doi.org/10.2174/1570180811209050942

DOI https://dx.doi.org/10.2174/1570180811209050942	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X