One-Step Synthesis of 1,2,5-Trisubstituted Pyrroles by Copper Catalyzed Condensation of 1,4-Diones with Primary Amines

Title:One-Step Synthesis of 1,2,5-Trisubstituted Pyrroles by Copper Catalyzed Condensation of 1,4-Diones with Primary Amines

Volume: 16 Issue: 20

Author(s): Rapelli Srinivas, Boningari Thirupathi, J. K. Prashanth Kumar, Avvari N. Prasad and Benjaram M. Reddy

Affiliation:

Keywords: CuI/C, Heterogeneous catalyst, Paal–Knorr condensation, N-Substituted pyrroles, Solvent-free, Montmorillonite, anhydrous Na2SO4, N-substituted pyrroles, substituents, hexadecylamine.

Abstract: Highly dispersed copper iodide on activated carbon (CuI/C) solid catalyst has been investigated for the Paal–Knorr condensation of γ-diketones with aliphatic, aromatic and heterocyclic amines under solvent-free conditions; which lead to the formation of N- substituted pyrrole derivatives in excellent yields. This simple experimental procedure combined with easy recovery and reusability of the catalyst is expected to contribute to the progression of a clean and ecofriendly strategy for the synthesis of N-substituted pyrrole derivatives.

Cite this article as:

Srinivas Rapelli, Thirupathi Boningari, K. Prashanth Kumar J., N. Prasad Avvari and M. Reddy Benjaram, One-Step Synthesis of 1,2,5-Trisubstituted Pyrroles by Copper Catalyzed Condensation of 1,4-Diones with Primary Amines, Current Organic Chemistry 2012; 16 (20) . https://dx.doi.org/10.2174/138527212803520182