Synthesis and Characterisation of 5-(6-substituted phenyl -2H-chromen-3- yl) Oxazole Derivatives

Palle      Sadanandam; Nomula      Sathaiah; Vantikommu      Jyothi; Murugulla      A. Chari; Donthabakthuni      Shobha; Parthasarathi      Das; Khagga      Mukkanti

doi:10.2174/157017812803521126

Abstract

Here we demonstrate the synthesis of various derivatives of 5-(6-substituted phenyl-2H-chromen-3-yl)- oxazoles 5(a-k) by using Suzuki coupling conditions with different substituted boronic acids and obtained 23-57 % yields. We also synthesised various derivatives of the 5-(substituted 2H-chromen-3-yl)-oxazoles 3(a-j) mediated by TOSMIC as a reagent and achieved 58-70 % yield.

Keywords: 5-(substituted 2H-chromen-3-yl)-oxazoles, 5-(6-substituted phenyl-2H-chromen-3-yl)-oxazoles, suzuki coupling, TOSMIC reagent, pharmaceutically significant, natural products, derivatives, human rhinovirus 3c protease, conjugate addition, antidiabetic activity

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Letters in Organic Chemistry

Title:Synthesis and Characterisation of 5-(6-substituted phenyl -2H-chromen-3- yl) Oxazole Derivatives

Volume: 9 Issue: 9

Author(s): Palle Sadanandam, Nomula Sathaiah, Vantikommu Jyothi, Murugulla A. Chari, Donthabakthuni Shobha, Parthasarathi Das and Khagga Mukkanti

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Abstract: Here we demonstrate the synthesis of various derivatives of 5-(6-substituted phenyl-2H-chromen-3-yl)- oxazoles 5(a-k) by using Suzuki coupling conditions with different substituted boronic acids and obtained 23-57 % yields. We also synthesised various derivatives of the 5-(substituted 2H-chromen-3-yl)-oxazoles 3(a-j) mediated by TOSMIC as a reagent and achieved 58-70 % yield.

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Sadanandam Palle, Sathaiah Nomula, Jyothi Vantikommu, A. Chari Murugulla, Shobha Donthabakthuni, Das Parthasarathi and Mukkanti Khagga, Synthesis and Characterisation of 5-(6-substituted phenyl -2H-chromen-3- yl) Oxazole Derivatives, Letters in Organic Chemistry 2012; 9 (9) . https://dx.doi.org/10.2174/157017812803521126