Abstract
Although organ transplantations have been broadly performed in humans, occurrence of rejection has not yet been resolved. Several inflammatory factors, such as cytokines and adhesion molecules, enhance the rejection. Specific treatments that target in the attenuation of rejection have not been well studied in organ transplantation. Recent progress in the nucleic acid drugs, such as antisense oligodeoxynucleotides (ODNs) to regulate the transcription of disease-related genes, are known to play critical roles in therapeutic applications. Transfection of cis-element double-stranded DNA, named as "decoy", has been also reported to be a useful nucleic acid drug. This strategy has been not only a useful method for the experimental studies of gene regulation but also a novel clinical strategy. In this article, we reviewed the experimental results of nucleic acid drugs using the experimental organ transplant models.
Keywords: Adhesion molecules, Antisense oligodeoxynucleotides, Cytokines, Inflammation, Nucleic acid drug, Transplantation
Current Topics in Medicinal Chemistry
Title:Applications of Nucleic Acid Drugs for Organ Transplantation
Volume: 12 Issue: 15
Author(s): Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita and Ryozo Nagai
Affiliation:
Keywords: Adhesion molecules, Antisense oligodeoxynucleotides, Cytokines, Inflammation, Nucleic acid drug, Transplantation
Abstract: Although organ transplantations have been broadly performed in humans, occurrence of rejection has not yet been resolved. Several inflammatory factors, such as cytokines and adhesion molecules, enhance the rejection. Specific treatments that target in the attenuation of rejection have not been well studied in organ transplantation. Recent progress in the nucleic acid drugs, such as antisense oligodeoxynucleotides (ODNs) to regulate the transcription of disease-related genes, are known to play critical roles in therapeutic applications. Transfection of cis-element double-stranded DNA, named as "decoy", has been also reported to be a useful nucleic acid drug. This strategy has been not only a useful method for the experimental studies of gene regulation but also a novel clinical strategy. In this article, we reviewed the experimental results of nucleic acid drugs using the experimental organ transplant models.
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Cite this article as:
Suzuki Jun-ichi, Isobe Mitsuaki, Morishita Ryuichi and Nagai Ryozo, Applications of Nucleic Acid Drugs for Organ Transplantation, Current Topics in Medicinal Chemistry 2012; 12 (15) . https://dx.doi.org/10.2174/156802612803531478
DOI https://dx.doi.org/10.2174/156802612803531478 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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