Abstract
C5-position in pyrimidine nucleosides and nucleotides is an invaluable anchor point for tagging diverse kind of labels like haptens, dyes and signaling molecules. Oligonucleotides with such C5-modified pyrimidine nucleosides and nucleotides are being used in molecular genetics and next generation nucleic acid sequencing as indispensable diagnostic tools. In view of their requirement in a wide range of primers and probes, chemistry synthesis and manufacture of C5-modified substituted pyrimidines had elicited continued interest over the last several decades. These diverse classes of molecules also have pharmaceuticals significance. The objective of this review is to capture the recent strategies available to synthesize C5-modified pyrimidine nucleosides and nucleotides that include organometallic, “Click” and photochemistry.
Keywords: Click chemistry, Organometallic coupling, C5-halopyrimidines, C5-substituted pyrimidine nucleosides, nucleotides, organometallic, photochemistry, Oligonucleotides, nucleotides and organometallic
Current Organic Chemistry
Title:Recent Developments in the Synthesis and Applications of C5-Substituted Pyrimidine Nucleosides and Nucleotides
Volume: 16 Issue: 17
Author(s): Anilkumar R. Kore and Irudaya Charles
Affiliation:
Keywords: Click chemistry, Organometallic coupling, C5-halopyrimidines, C5-substituted pyrimidine nucleosides, nucleotides, organometallic, photochemistry, Oligonucleotides, nucleotides and organometallic
Abstract: C5-position in pyrimidine nucleosides and nucleotides is an invaluable anchor point for tagging diverse kind of labels like haptens, dyes and signaling molecules. Oligonucleotides with such C5-modified pyrimidine nucleosides and nucleotides are being used in molecular genetics and next generation nucleic acid sequencing as indispensable diagnostic tools. In view of their requirement in a wide range of primers and probes, chemistry synthesis and manufacture of C5-modified substituted pyrimidines had elicited continued interest over the last several decades. These diverse classes of molecules also have pharmaceuticals significance. The objective of this review is to capture the recent strategies available to synthesize C5-modified pyrimidine nucleosides and nucleotides that include organometallic, “Click” and photochemistry.
Export Options
About this article
Cite this article as:
R. Kore Anilkumar and Charles Irudaya, Recent Developments in the Synthesis and Applications of C5-Substituted Pyrimidine Nucleosides and Nucleotides, Current Organic Chemistry 2012; 16 (17) . https://dx.doi.org/10.2174/138527212803251622
DOI https://dx.doi.org/10.2174/138527212803251622 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients. Five Years Literature Review
Reviews on Recent Clinical Trials Novel Structurally Varied N-Alkyl 1,4-Dihydropyridines as ABCB1 Inhibitors: Structure-Activity Relationships, Biological Activity and First Bioanalytical Evaluation
Medicinal Chemistry Objective Biomarkers or Symptom Scores for the Classification of Fibromyalgia Syndrome?
Current Rheumatology Reviews Grinding Synthesis of Pyrazolyl-Bis Coumarinyl Methanes Using Potassium 2-Oxoimidazolidine-1,3-diide
Current Organic Synthesis Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma
Combinatorial Chemistry & High Throughput Screening From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives
Letters in Organic Chemistry Synthesis and Evaluation of Vascular Endothelial Growth Factor Receptor-2 Inhibitory Activity of 6,7-Dimethoxycinnoline Derivatives
Letters in Drug Design & Discovery A Three-gene-based Type 1 Diabetes Diagnostic Signature
Current Pharmaceutical Design What Can Neuroscience Tell Us About the Potential of Psychedelics in Healthcare? How the Neurophenomenology of Psychedelics Research Could Help us to Flourish Throughout Our Lives, as Well as to Enhance Our Dying
Current Drug Abuse Reviews Novel 1, 2, 3-Triazole-Linked Norcantharidin Analogues: Synthesis and Evaluation of Growth Inhibition in a Panel of Selected Tumor-Cell Lines
Letters in Drug Design & Discovery Anti-Inflammatory Responses of Resveratrol
Inflammation & Allergy - Drug Targets (Discontinued) Melamine Derivatives - A Review on Synthesis and Application
Current Organic Synthesis An Automatic Glioma Segmentation System Using a Multilevel Attention Pyramid Scene Parsing Network
Current Medical Imaging Synthetic and Natural Products as Iron Chelators
Current Topics in Medicinal Chemistry Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechnology for Treating Cognitive Deficits, Depression and Intellectual Disabilities
Current Pharmaceutical Biotechnology Recent Progress in Synthesis, Vibrational Characterization and Applications Trend of Conjugated Polymers/Carbon Nanotubes Composites
Current Organic Chemistry Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation
Current Medicinal Chemistry Meta Analysis of Advanced Cancer Survival Data Using Lognormal Parametric Fitting: A Statistical Method to Identify Effective Treatment Protocols
Current Pharmaceutical Design Recent Patent-Based Perspective on Diagnostic and Therapeutic Interventions in Malignant Mesothelioma: Is Drug Repositioning Knocking on the Door?
Recent Patents on Anti-Cancer Drug Discovery Epidemics and Peptide Vaccine Response: A Brief Review
Current Topics in Medicinal Chemistry