Abstract
Ensuring the appropriate spatial-temporal control of protein abundance requires careful control of transcript levels. This process is regulated at many steps, including the rate at which transcripts decay. microRNAs (miRNAs) and RNA Binding Proteins (RBPs) represent two important regulators of transcript degradation. We review here recent literature that suggests these two regulators of transcript decay may functionally interact. Some studies have reported an excess of miRNA binding sites surrounding the positions at which RBPs bind. Experimental reports focusing on a particular transcript have identified instances in which RBPs and miRNAs compete for the same target sites, and instances in which the binding of a RBP makes a miRNA recognition site more accessible to the RISC complex. Further, miRNAs and RBPs use similar enzymes for degradation of target transcripts and the degradation of the target transcripts occurs in similar subcellular compartments. In addition to miRNA-RBP interactions involving transcript decay, RBPs have also been reported to facilitate the processing of pri-miRNAs to their final form. We summarize here several possible mechanisms through which miRNA-RBP interactions may occur.
Keywords: microRNAs, RNA binding proteins, Pumilio, AU-rich elements, transcript decay, Immunoprecipitation, ribosomes, photoactivatable, ribonucleoside, thiouridine.
MicroRNA
Title:Functional Interactions Between microRNAs and RNA Binding Proteins
Volume: 1 Issue: 1
Author(s): Peng Jiang and Hilary Coller
Affiliation:
Keywords: microRNAs, RNA binding proteins, Pumilio, AU-rich elements, transcript decay, Immunoprecipitation, ribosomes, photoactivatable, ribonucleoside, thiouridine.
Abstract: Ensuring the appropriate spatial-temporal control of protein abundance requires careful control of transcript levels. This process is regulated at many steps, including the rate at which transcripts decay. microRNAs (miRNAs) and RNA Binding Proteins (RBPs) represent two important regulators of transcript degradation. We review here recent literature that suggests these two regulators of transcript decay may functionally interact. Some studies have reported an excess of miRNA binding sites surrounding the positions at which RBPs bind. Experimental reports focusing on a particular transcript have identified instances in which RBPs and miRNAs compete for the same target sites, and instances in which the binding of a RBP makes a miRNA recognition site more accessible to the RISC complex. Further, miRNAs and RBPs use similar enzymes for degradation of target transcripts and the degradation of the target transcripts occurs in similar subcellular compartments. In addition to miRNA-RBP interactions involving transcript decay, RBPs have also been reported to facilitate the processing of pri-miRNAs to their final form. We summarize here several possible mechanisms through which miRNA-RBP interactions may occur.
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Cite this article as:
Jiang Peng and Coller Hilary, Functional Interactions Between microRNAs and RNA Binding Proteins, MicroRNA 2012; 1 (1) . https://dx.doi.org/10.2174/2211536611201010070
DOI https://dx.doi.org/10.2174/2211536611201010070 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
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