Abstract
MicroRNAs (miRNAs) are endogenous non-coding RNAs that play critical roles in regulating transcription in eukaryotes. miRNAs are involved in a wide-range of biological processes. Because miRNA research is relatively new, it is not surprising that tools and techniques to study their biology are still being developed. Our laboratory is interested in carefully delineating the in vivo expression patterns between three closely related miR-7 miRNA family members in the mouse. The miR-7 family of miRNAs is conserved between humans and invertebrates. The miR-7 family also shows conserved expression in neural tissues, and members of this family are involved in the development of sensory structures in flies, associated with many types of cancer, and likely play a role in osmoregulation in the mouse brain. In this study, we used multiple methods to differentiate the expression of the miR-7 family members in the mouse brain. Our results suggest that although there are useful tools for exploring miRNA expression in vivo, better tools and/or methods are still needed for thorough in vivo studies of closely related family members.
Keywords: microRNA, brain, family, in vivo, expression, glioblastoma, paraventricular nucleus (PVN), hybridization, amygdala, hippocampus.
MicroRNA
Title:Investigating the In Vivo Expression Patterns of miR-7 microRNA Family Members in the Adult Mouse Brain
Volume: 1 Issue: 1
Author(s): Nicholas A. Sanek and W. Scott Young
Affiliation:
Keywords: microRNA, brain, family, in vivo, expression, glioblastoma, paraventricular nucleus (PVN), hybridization, amygdala, hippocampus.
Abstract: MicroRNAs (miRNAs) are endogenous non-coding RNAs that play critical roles in regulating transcription in eukaryotes. miRNAs are involved in a wide-range of biological processes. Because miRNA research is relatively new, it is not surprising that tools and techniques to study their biology are still being developed. Our laboratory is interested in carefully delineating the in vivo expression patterns between three closely related miR-7 miRNA family members in the mouse. The miR-7 family of miRNAs is conserved between humans and invertebrates. The miR-7 family also shows conserved expression in neural tissues, and members of this family are involved in the development of sensory structures in flies, associated with many types of cancer, and likely play a role in osmoregulation in the mouse brain. In this study, we used multiple methods to differentiate the expression of the miR-7 family members in the mouse brain. Our results suggest that although there are useful tools for exploring miRNA expression in vivo, better tools and/or methods are still needed for thorough in vivo studies of closely related family members.
Export Options
About this article
Cite this article as:
A. Sanek Nicholas and Scott Young W., Investigating the In Vivo Expression Patterns of miR-7 microRNA Family Members in the Adult Mouse Brain, MicroRNA 2012; 1 (1) . https://dx.doi.org/10.2174/2211536611201010011
DOI https://dx.doi.org/10.2174/2211536611201010011 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Food and Food Supplements with Hypocholesterolemic Effects
Recent Patents on Food, Nutrition & Agriculture Fibroblast Growth Factor Receptor (FGFR): A New Target for Non-small Cell Lung Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Organ Preference of Cancer Metastasis and Metastasis-Related Cell Adhesion Molecules Including Carbohydrates
Cardiovascular & Hematological Disorders-Drug Targets Diabetes, Cancer and Treatment – A Mini-Review
Current Drug Safety Anti-cancer Effects of Curcumin on Head and Neck Cancers
Anti-Cancer Agents in Medicinal Chemistry Toll-Like Receptors in the Cycling Female Reproductive Tract and During Pregnancy
Current Women`s Health Reviews Estrogen and Female Lower Urinary Tract Dysfunction
Current Women`s Health Reviews Personalizing HER2-Targeted Therapy in Metastatic Breast Cancer Beyond HER2 Status: What We Have Learned from Clinical Specimens
Current Pharmacogenomics and Personalized Medicine Recent Advances in the Synthesis and Anticancer Activity of Some Molecules Other Than Nitrogen Containing Heterocyclic Moeities
Mini-Reviews in Medicinal Chemistry Molecular Targets for Nutritional Preemption of Cancer
Current Cancer Drug Targets Privileged Scaffolds Targeting Bromodomain-containing Protein 4
Current Topics in Medicinal Chemistry Organosulfur Compounds in Cancer Chemoprevention
Mini-Reviews in Medicinal Chemistry Implications of the Molecular Basis of Prostacyclin Biosynthesis and Signaling in Pharmaceutical Designs
Current Pharmaceutical Design Recent Developments in Female Hormonal Contraception
Current Women`s Health Reviews A Review of Natural and Synthetic Antioxidants Important for Health and Longevity
Current Medicinal Chemistry Multifactorial Regulation of GPER Expression in Cancer Cells and Cardiomyocytes
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) A Review on Antiproliferative and Apoptotic Activities of Natural Honey
Anti-Cancer Agents in Medicinal Chemistry Functional Foods: Salient Features and Clinical Applications
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Highlights on Medical Treatment of Uterine Fibroids
Current Pharmaceutical Design Sulfotransferase 1A1 as a Biomarker for Susceptibility to Carcinogenesis: From Molecular Genetics to the Role of Dietary Flavonoids
Current Drug Metabolism