Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences"

Title:Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences"

Volume: 19 Issue: 11

Author(s): Keiko Hojo, Hideki Ichikawa, Asaki Hara, Mare Onishi, Koichi Kawasaki and Yoshinobu Fukumori

Affiliation:

Keywords: Solid-phase synthesis, Fmoc-amino acid, synthesis in water, difficult sequence, nanoparticles, microwave-assisted synthesis

Abstract: A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.

Cite this article as:

Hojo Keiko, Ichikawa Hideki, Hara Asaki, Onishi Mare, Kawasaki Koichi and Fukumori Yoshinobu, Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences", Protein & Peptide Letters 2012; 19 (11) . https://dx.doi.org/10.2174/092986612803217114