Hepatocyte Growth Factor in Normal and Diseased Bone and Joint Tissues

Title: Hepatocyte Growth Factor in Normal and Diseased Bone and Joint Tissues

Volume: 2 Issue: 1

Author(s): Iannis E. Adamopoulos and Nicholas A. Athanasou

Affiliation:

Keywords: HGF, c-Met, Rheumatoid Arthritis, Osteoarthritis, Osteoclasts, Bone resorption

Abstract: Hepatocyte Growth Factor (HGF) is a multifunctional growth factor which, like its receptor c-Met, is widely expressed in osteoarticular tissues. HGF has profound effects on cell motility and differentiation and tissue morphogenesis and angiogenesis. HGF plays an important role in normal bone and cartilage turnover. Changes in HGF/c-Met have also been linked to pathophysiological changes in several bone and joint disorders. HGF has been implicated in the pathogenesis of inflammatory changes in rheumatoid synovium and in degenerative changes in osteoarthritis. HGF also influences bone remodelling and has significant effects on the proliferation and differentiation of osteoclast precursors, osteoclast activity and survival. A therapeutic role of HGF also has been proposed in the regeneration of osteoarticular tissues.

Cite this article as:

Adamopoulos E. Iannis and Athanasou A. Nicholas, Hepatocyte Growth Factor in Normal and Diseased Bone and Joint Tissues, Current Rheumatology Reviews 2006; 2 (1) . https://dx.doi.org/10.2174/1573397110602010001

DOI https://dx.doi.org/10.2174/1573397110602010001	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360