Cachexia and Herbal Medicine: Perspective

Hajime      Suzuki; Akihiro      Asakawa; Haruka      Amitani; Norifumi      Nakamura; Akio      Inui

doi:10.2174/138161212803216960

Abstract

Kampo, a form of traditional herbal medical practice, has become a substance of interest for scientific research. Although earlier clinical reports concerning Kampo are abundant, the scientific investigation of Kampo has a very short history. However, the process of acquiring quantifiable clinical trial evidence on herbal medicine is now clearly underway. The development of multi-component herbal medicines capable of targeting multiple sites could be useful both for future drug discovery and for the potential management of complex diseases. Additionally, mechanistic studies and the identification of active compounds could lead to new discoveries in the biological and biomedical sciences. Modern translational research on herbal medicines beyond basic science and clinical perspectives will contribute to the development of new medicines. This review covers the translational aspects of herbal medicine with a focus on cancer anorexiacachexia. The review gives perspective on a new horizon for herbal medicine from a scientific point of view and a basis for the further development of complementary and alternative medicine (CAM) for patients.

Keywords: Cancer anorexia-cachexia syndrome, complementary and alternative medicine, herbal medicine, Kampo, feeding-regulatory peptide, sarcopenia, cytokine, translational approach, active compounds, complementary and alternative medicine (CAM).