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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies

Author(s): Max V. Ranall, Mark S. Butler, Mark A. Blaskovich and Matthew A. Cooper

Volume 13, Issue 11, 2012

Page: [1375 - 1385] Pages: 11

DOI: 10.2174/138945012803530251

Price: $65

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Abstract

Biofilms formed by pathogenic bacteria present a serious threat to human health as the efficacy of standard antibiotic therapeutic regimens is compromised by reduced microbial susceptibility within the biofilm environment. The discovery of improved therapies for biofilm elimination requires an understanding of biofilm formation and dispersal, and the development of assays to specifically analyze these dynamic processes. This review will discuss biofilm screening strategies suitable for drug discovery efforts, especially chemical and biological approaches that specifically target biofilm destruction.

Keywords: Antibiotic, antibiotic resistance, bacteria, biofilm, drug discovery, infection, screening, pathogenic bacteria, assays.


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