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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines

Author(s): Majid Ghashang

Volume 9, Issue 7, 2012

Page: [497 - 502] Pages: 6

DOI: 10.2174/157017812802139564

Abstract

The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.

Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant


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