Liposaccharides for Improved Oral Delivery of Tobramycin

Title:Liposaccharides for Improved Oral Delivery of Tobramycin

Volume: 2 Issue: 2

Author(s): Adel S. Abdelrahim, Pavla Simerska and Istvan Toth

Affiliation:

Keywords: Charged liposaccharide, tobramycin, absorption enhancer, drug delivery.

Abstract: Many drugs have limited penetration through the gastrointestinal tract and therefore cannot be administered orally. The aim of this study was to develop charged liposaccharide absorption enhancers to improve oral bioavailability of model drug tobramycin. In vitro experiments, haemolysis, and cytotoxicity tests confirmed that the synthesized liposaccharides were non-toxic at the concentrations used for oral administration. The partitioning coefficient of tobramycin was improved to an acceptable range for oral delivery (log P = 1-3), when it was mixed with anionic liposaccharides at molar ratio of 1:7.

Cite this article as:

S. Abdelrahim Adel, Simerska Pavla and Toth Istvan, Liposaccharides for Improved Oral Delivery of Tobramycin, Drug Delivery Letters 2012; 2 (2) . https://dx.doi.org/10.2174/2210304x11202020092