Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents

Silvia      Franchini; Annalisa      Tait; Claudia      Sorbi; Livio      Brasili

doi:10.2174/157340612802084162

Abstract

A series of 1,3-oxathiolane-based nucleoside analogs 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.

Keywords: 5-methyl-1, 3-oxathiolanes, Antiviral, NMR, Nucleosides, Stereochemistry, Synthesis, AIDS, RNA, DNA, drugs

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Medicinal Chemistry

Title:Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents

Volume: 8 Issue: 5

Author(s): Silvia Franchini, Annalisa Tait, Claudia Sorbi and Livio Brasili

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Keywords: 5-methyl-1, 3-oxathiolanes, Antiviral, NMR, Nucleosides, Stereochemistry, Synthesis, AIDS, RNA, DNA, drugs

Abstract: A series of 1,3-oxathiolane-based nucleoside analogs 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.

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Franchini Silvia, Tait Annalisa, Sorbi Claudia and Brasili Livio, Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents, Medicinal Chemistry 2012; 8 (5) . https://dx.doi.org/10.2174/157340612802084162