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Current Vascular Pharmacology

Editor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Therapeutic Potential and Strategies Against Leukocyte-Platelet Interaction in Atherosclerosis

Author(s): Peter Seizer and Andreas E. May

Volume 10, Issue 5, 2012

Page: [550 - 554] Pages: 5

DOI: 10.2174/157016112801784585

Price: $65

Abstract

Leukocyte rolling, adhesion, transmigration and activation are features of vascular inflammation leading to atherosclerosis. In particular the interaction between platelets and leukocytes is a key process for adhesion of inflammatory cells to the vascular wall. The various mechanisms of the specific platelet-leukocyte interaction may provide a powerful target to prevent initiation and/or progression of atherosclerotic lesions.

Keywords: Atherosclerosis, EMMPRIN, monocytes, platelets, pharmacological inhibition, inflammation, P-Selectin, clopidogrel, cytokines, chemokines


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