Abstract
A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4- bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.
Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer
Letters in Drug Design & Discovery
Title:2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents
Volume: 9 Issue: 7
Author(s): M. Senthilraja, V. Alagarsamy and V. Raja Solomon
Affiliation:
Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer
Abstract: A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4- bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.
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Senthilraja M., Alagarsamy V. and Raja Solomon V., 2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents, Letters in Drug Design & Discovery 2012; 9 (7) . https://dx.doi.org/10.2174/157018012801319517
DOI https://dx.doi.org/10.2174/157018012801319517 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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