TBAF-Assisted Palladium-Catalyzed Suzuki Reaction in Water Under the Ligand and Base-Free Conditions

Xiang-Mei      Wu; Yong-Bing      Gu

doi:10.2174/157017812801322408

Abstract

Tetrabutyl ammonium fluoride (abbreviated as TBAF)-assisted palladium-catalyzed Suzuki reaction in neat water has been demonstrated under the ligand and base-free conditions. The cross-coupling of aryl or heteroaryl bromides with arylboronic acids generated the corresponding products in good to excellent yields in the presence of low concentration of palladium acetate in combination with TBAF under air.

Keywords: Arylboronic acid, palladium, suzuki reaction, TBAF, water, N-heterocyclic carbenes, arylimines, ary(heteroaryl)oximes, Suzuki reaction, triphenylphosphine

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Letters in Organic Chemistry

Title:TBAF-Assisted Palladium-Catalyzed Suzuki Reaction in Water Under the Ligand and Base-Free Conditions

Volume: 9 Issue: 6

Author(s): Xiang-Mei Wu and Yong-Bing Gu

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Keywords: Arylboronic acid, palladium, suzuki reaction, TBAF, water, N-heterocyclic carbenes, arylimines, ary(heteroaryl)oximes, Suzuki reaction, triphenylphosphine

Abstract: Tetrabutyl ammonium fluoride (abbreviated as TBAF)-assisted palladium-catalyzed Suzuki reaction in neat water has been demonstrated under the ligand and base-free conditions. The cross-coupling of aryl or heteroaryl bromides with arylboronic acids generated the corresponding products in good to excellent yields in the presence of low concentration of palladium acetate in combination with TBAF under air.

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Wu Xiang-Mei and Gu Yong-Bing, TBAF-Assisted Palladium-Catalyzed Suzuki Reaction in Water Under the Ligand and Base-Free Conditions, Letters in Organic Chemistry 2012; 9 (6) . https://dx.doi.org/10.2174/157017812801322408