Abstract
Ocular iontophoresis is a time tested non-invasive tool for efficient delivery of drugs to both anterior and posterior segments of the eye. The review focuses on history of ocular iontophoresis, recent research developments on transcorneal/transscleral iontophoresis, prominent patents issued and filed on novel iontophoresis devices along with their treatment regimens. The review provides detailed information on development of ophthalmic iontophoretic devices, mode of action and the potential therapeutic applications. Further, the review discusses important clinical trials completed or inprogress on ocular iontophoresis targeting complex ocular disease states. A literary review of important developments in ophthalmic iontophoresis is expected to explore the growing prominence of this technique to effectively deliver drugs to both the superficial and inner ocular compartments targeting complex disease states as Glaucoma and Age Related Macular Degeneration.
Keywords: Clinical trials, EyeGate® II Delivery System®, Patents in ocular iontophoresis, Ocuphor® delivery system, targeted iontophorectic drug delivery, Transscleral iontophoresis, transcorneal iontophoresis, Visulex® delivery system
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